Robert J. and Nancy D. Carney Institute for Brain Science

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Dopaminergic therapy and deep brain stimulation can improve the motor symptoms of Parkinson’s disease (PD). But both treatments can make patients more impulsive. In a new study, Carney researchers combined experimental testing with computational modeling to uncover two different routes the two treatments take to modify decision-making.
Many people are wired to seek and respond to rewards. Your brain interprets food as rewarding when you are hungry and water as rewarding when you are thirsty. But addictive substances like alcohol and drugs of abuse can overwhelm the natural reward pathways in your brain, resulting in intolerable cravings and reduced impulse control.