Robert J. and Nancy D. Carney Institute for Brain Science

Genetically Modified Nematodes

Nematodes are tiny, living worms (as small as the period at the end of this sentence) modified by the gene-editing tool CRISPR to contain human mutations for four types of amyotrophic lateral sclerosis, or ALS, as well as Huntington’s disease and frontotemporal dementia.

Why it’s Important

This collection of modified animals is a fast, cheap way to conduct research on neurodegenerative diseases, speeding innovation and making science more accessible.

What it Does

In production for more than 20 years, these are the first nematodes to explicitly model human neurodegenerative diseases. They are used to study brain cell death and identify drug targets for neurodegenerative diseases.

Where it’s Used

Researchers in dozens of science labs across the country and around the world, as well as high school and college students studying biology, use Hart’s genetically modified nematodes.